Due to the shortcomings of conventional liposomes, such as low targeting, poor stability, and susceptibility to destruction by hydrolytic enzymes, it is often necessary to modify liposomes to compensate for their shortcomings or to enhance certain functional advantages in applications. Such modification strategies can be easily functionalized by introducing functional materials to increase the application potential of liposomes. Lifeasible provides professional, functional liposome development services to modify liposomes with various functional molecules to broaden the application areas of liposomes.
Spatially sterically stabilized liposomes are novel liposomes containing lipid-like derivatives modified with natural or synthetic polymers on their surface. The types of modified polymers are polyethylene glycol (PEG), polypropylene phthalamide (PPA), polyvinyl viologen (PVP), etc., of which polyethylene glycol (PEG) is the more commonly used one. The molecules are covalently bonded with phospholipid molecules to form derivatized phospholipids, which can effectively protect liposomes and improve their physical, chemical, and biological stability.
Various strategies have been developed, including coating liposomes with natural or hydrophobic polysaccharides. Polysaccharide coatings tend to be physicochemically stable and site-specific vesicle structures in the biological environment. In developing polysaccharide-anchored liposomes, it is important to consider the mechanism and method of polysaccharide binding to the bilayer and the effect on the permeability, fluidity, and integrity of the bilayer.
Liposomes are excellent candidates for bubble encapsulation to increase blood echogenicity. In addition, imaging liposomes are widely used in positron emission tomography (PET), fluorescence imaging (FLI), and photoacoustic imaging (PAI) for targeted accumulation or real-time imaging and tracking.
Lifeasible has many years of experience in liposome development. Based on advanced technology and comprehensive lab equipment means, we can develop unique liposome formulations and services. By changing liposomes' physical and chemical properties, we can rationally design and develop liposomes so that our customers are satisfied with our services.
We develop PEGylated liposomes suitable for customer requirements based on the molecular weight, shape, reactivity, specificity, and bond type of the PEG component, as well as the physicochemical properties of the small molecule itself.
A variety of different polysaccharide modifications can be developed on liposomes according to requirements, and the affinity and selectivity of the polysaccharide selection for its complementary ligands are ideal prerequisites for a system with site-specific and targeted properties.
In addition to the above functional liposome development services, we can also customize other related liposome development services for you.
Physical testing - vesicle shape, size and morphology, surface charge, dispersed phase behavior, liposome encapsulation efficiency.
Chemical testing - phospholipid concentration, cholesterol concentration, etc.
Biological testing - to determine safety for use in functional liposomes.
If you are interested in our services, or if the service you want is not listed, please feel free to contact us, and we will get back to you as soon as possible.
