Analysis Spectrum-Effect Relationship of Herbal Medicines

Inquiry

The herbal spectrum-effect relationship is based on herbal fingerprinting, with effect as the main content, and the application of bioinformatics methods, which can extract the intrinsic relationship between herbal fingerprinting and the quality and efficacy of herbal medicines. Lifeasible has developed a system of herbal genealogy by acquiring, processing, and mining information from herbal fingerprints, as well as researching the correlation between fingerprint information and pharmacological activity information, thus realizing the transformation of herbal chemical fingerprints into herbal pharmacological component fingerprints, and forming a system of herbal genealogy.

We use a variety of analytical tools for the spectrum-effect analysis of herbs, including high-performance liquid chromatography (HPLC), ultra-performance liquid chromatography (UPLC), gas chromatography (GC), etc.

The multi-component, multi-target, and multi-pathway synergistic characteristics of herbal medicines determine the differences between the methods of evaluating the efficacy of herbal medicines and those of traditional chemical medicines. Currently, our pharmacodynamic analysis includes in vitro and in vivo experiments. In vitro, tests can reflect the pharmacodynamic activity of herbal drugs more visually, while in vivo tests are more consistent with the actual pharmacodynamic effects of herbal drugs.

At the same time, we used correlation analysis methods to relate the obtained herbal fingerprints to the pharmacodynamic effects, including regression analysis, correlation analysis, grey correlation analysis, principal component analysis, artificial neural network, cluster analysis, etc. Different statistical methods can significantly impact the final results, so we apply several different statistical methods to the data obtained for the same herb or compound and integrate the results to reach a reliable conclusion.

Applications

To determine the active ingredients of single and compounded medicines by studying the correlation between fingerprint profiles and their corresponding pharmacodynamics.
Based on the tracing of the active substances, guides the optimization of their preparation processes.
Prediction and control of the efficacy of herbal medicines are achieved by using the corresponding spectrum-effect relationship equations.
Spectrum-effect analysis can be used for quality control studies of herbs of different origins, as multiple origins and sources are one of the characteristics of herbal medicines.

Spectrum-effect has the feature of correlating herbal fingerprints with actual efficacy, and this feature can provide great convenience in inferring the efficacy of herbal medicines based on fingerprints. Lifeasible can apply genealogical relationships to predict the efficacy of herbs; please feel free to contact us for more information.

For Research Use Only. Not For Clinical Use.