Biotransformation of Herbal Medicines

Inquiry

The active ingredients in herbal medicines are mostly natural products of medicinal plants, and their biosynthesis involves various complex biochemical processes in the body. However, natural products of medicinal plants often suffer from low content, low extraction efficiency, high cost, and low bioavailability, and some are even toxic. Biotransformation refers to the physiological and biochemical reactions that occur when exogenous substrates are modified or structurally modified using biological systems or related enzymes of biological systems. Biotransformation is a powerful and diverse system of biological enzymes that can overcome the challenges of modifying or modifying chemical structures that are difficult to achieve with traditional research methods. Lifeasible can help you to obtain naturally rare substances or novel active chemical structures at a lower cost, thus expanding your choice of sources to facilitate the development of new herbal medicines.

Biotransformation of herbal medicines

Hydroxylation reactions. Overcomes the bottleneck of traditional organic chemistry methods that make it challenging to hydroxylate accurately and efficiently in a safe manner.
Hydrolysis reactions. Hydrolysis of glycosides, proteins and peptides, esters, and other herbal and natural drugs. By optimizing the reaction conditions and optimizing the genes for cloning enzymes, we will exploit the strengths of hydrolysis reactions and help you to better apply them to the development of herbal and natural medicines.
Oxidation reactions. The main focus is on hydroxyl oxidation, carbonyl oxidation, and epoxidation. We use the intermediates of chiral compounds generated by epoxidation reactions to play an essential role in studying chiral drugs. And the research and development of asymmetric epoxidation reactions that we help you to carry out can provide the basis for the efficacy and safety of chiral drugs, as well as more economical and safer conditions for their administration.
Reduction reactions. We use reductases to catalyze reduction reactions, which have significant advantages over traditional chemical reduction methods, including high efficiency and environmental friendliness.
Glycosylation. Our glycosylation reactions result in glycosylated products with high stability, high water solubility, and low cytotoxicity, which allow for better efficacy and contribute to the production and development of drugs.

Applications

Expanding the source of drugs and providing a basis for new drug development
Reducing adverse effects and optimizing production processes
As an in vitro model to aid drug metabolism studies

Biotransformation has excellent potential to generate new compounds or to produce known compounds more efficiently. Lifeasible uses biotransformation to obtain biologically active compounds that are difficult to prepare by traditional synthetic chemistry, which is more economical, safer, and more regioselective and stereoselective than traditional chemical synthesis. The structural modification or modification of the original active substance by enzymatic systems substantially expands the range of highly active and less toxic active substances available for screening, which promises to help you solve the toxicity problems of certain herbs and widen the path for applying herbal active ingredients. We are already well established; please feel free to contact us for new drug development and application of herbal medicines.

For Research Use Only. Not For Clinical Use.