Evaluation of Biological Activity of Herbal Components

The chemical composition of herbs is complex and except for a very few mineral remedies, every single herb contains the equivalent of a library of compounds. Not all of these many types of compounds are active molecules. The specific pharmacological activity of herbs is often directly related to certain groups of molecules with certain structural characteristics. Lifeasible uses modern technology to elucidate the material basis of herbs and is an essential tool in your research to improve the efficacy and stabilize the quality of herbal medicines. We can help you to identify the chemical groups that play a therapeutic role in herbal medicine or to clarify the material basis of herbal medicine's efficacy.

Holistic efficacy assessment screening method

Animal-level efficacy assessment is the best way to measure the efficacy and toxicity of a drug at a holistic level, and the results are closest to human trials. We have animal models of various diseases such as hypertension, hyperlipidemia, diabetes, etc. We can use animal models of diseases for efficacy assessment. The results of the overall animal-level efficacy assessment are closest to human trials and are in line with the multi-targeted action of herbal medicines.

Cellular level activity assessment method

To solve the problem of long lead times in holistic efficacy assessment screening methods, we also offer our customers a variety of cellular models for active ingredient screening. We can provide a minimal and relatively complete biological system for the screening of active ingredients in herbal medicines, and the use of cultured cells for active ingredient screening is cost-effective and has a short cycle time. The in vitro cellular level activity evaluation method improves the specificity and sensitivity of identifying target components from complex herbal ingredient systems and enables large-scale, high-throughput screening.

• Cellular models for anti-tumour drug screening
• Cellular models for drug evaluation and screening for cell protection
• Cellular models for specific target receptor screening

Biomolecular level activity assessment method

This method belongs to target receptors or enzymes' in vitro screening mode. If a critical signaling pathway has been proven to be closely related to a physiological or pathological link, then we use the critical receptor or enzyme on that signaling pathway as a probe to screen for activators and inhibitors of the target receptor, or catalysts, inhibitors, and substrates of the target enzyme from a wide range of herbal components to discover drug candidates.

• No reliance on animal models and cells
• Low volume of samples required
• Short cycle time and low cost
• Automated process
• Significantly increased throughput and scale of screening

The complexity of herbal components and the diversity of their targets make it challenging to assess their biological activity. Lifeasible combines the use of activity assays with various chromatographic and mass spectrometric techniques to establish a model for the evaluation of the overall efficacy of a wide range of herbal active ingredients, cellular level activity, and biomolecular level activity, helping you to discover new natural active ingredients or new biological activities of multiple herbal ingredients. Please feel free to contact us to start your project.

• High Throughput Screening of Active Ingredients in Herbal Medicines
• Screening and Compounding of Herbal Medicinal Component Groups
• Development of Lead Compounds in Herbal Medicines