High Throughput Screening of Active Ingredients in Herbal Medicines

Inquiry

Traditional drug screening methods use pharmacological experimental methods to evaluate the pharmacological activity of medicinal samples through various in vivo and in vitro experimental methods. However, as traditional pharmacological methods require the consumption of a large number of samples, the use of a large number of experimental animals, the skilled operation skills of the technicians participating in the experiments, and the limited amount of samples to be screened, they are labor intensive and cannot accommodate the simultaneous screening of a large number of samples. High throughput drug screening (HTS) is based on traditional screening techniques, applying advanced molecular biology, cell biology, computers, automation control, and other high technology to establish a more suitable drug screening technology system. Lifeasible's HTS is a highly efficient and effective method for the simultaneous analysis of large numbers of samples for biological or pharmacological activity. We apply the latest technology in modern drug screening to herbal medicine, which will significantly support you in your herbal medicine modernization research.

High throughput screening of active ingredients in herbal medicines

We use HTS as the basis for molecular and cellular methods, microplates as the vehicle for experiments, an automated operating system to perform the experiments, sensitive and fast instruments to collect the data, and a computer to analyze and process the data obtained. Thousands or tens of thousands of samples are tested simultaneously, and a corresponding database supports the entire system.

Applications

Classification studies of herbal medicines.
We can carry out large-scale comparative screening according to different classes of drugs according to the traditional drug classification method to study the commonalities and characteristics of the actions of different classes of drugs. By studying the mechanisms of action of different classes of herbal medicines, we can find out where the differences between the various classes of medicines lie.
Identifying herbs and studying changes in composition and potency before and after concoction.
There are many different herbal medicines, and the identification features are not obvious. We use the HTS method to identify herbal medicines quickly and efficiently with high throughput.
Large-scale screening of herbal medicine effectiveness.
In the face of a large number of herbal medicines, high-throughput drug screening methods are a fast and effective method.
Research and discovery of active ingredients in herbal medicines.
With the help of new sample preparation methods and equipment, we can extract different samples, including single compounds, extracted fractions, or parts. The screening of the activity of single compound components of herbal medicines allows a direct evaluation of the compounds' biological activity and pharmacological action based on the results obtained. However, for extracts or parts containing multiple components, the extraction and separation can be followed up based on the activity results to ultimately discover the active compound or identify the active component.
Mechanism of action studies of herbal medicines.
Applying the HTS method allows us to carry out an in-depth study of the principles of action of herbal medicines. Different drug screening models are used to study the pharmacological effects of different components of herbal medicines and to elucidate the mechanisms by which herbal medicines act in the therapeutic process.
Herbal compounding studies.
Using the HTS method, we can screen the combination, ratio, and active site of herbal compounds. Based on the screening results, we can analyze the principles of compounding and determine the best compound composition to improve the therapeutic effect of the compound. It is also possible to obtain active components with more desirable effects and develop new compounded drug types.

The application of modern science and technology to the study of active ingredients in herbal medicines is an essential element in the modernization of herbal medicines, and the HTS method is a scientific research tool that can be applied not only in these areas but also the evaluation of the efficacy, metabolism, toxicity, and side effects of herbal medicines and as a technical platform for the screening of new herbal medicines. The HTS method offered by Lifeasible offers significant advantages in terms of speed and efficiency in studying the active ingredients contained in herbal medicines, especially in the study of large numbers of herbal medicines. Please feel free to contact us for your research.

For Research Use Only. Not For Clinical Use.