Technical Information

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Herbal medicines are complex systems with multiple components, multiple targets, and synergistic interactions between them. Because of the complexity of their components and the size of their systems, it is tough to explore their effects on the body from a mixture of systems. Lifeasible provides systems pharmacology-based techniques and methods to help you investigate the mechanisms of herbal medicines. We aim to develop mathematical and computational models that integrate data at several spatial and temporal scales for complex systems of herbal medicines and to model the interactions between multiple elements (e.g., drug molecules, targets, cells, tissues, organs, etc.) to elucidate and predict the mechanisms of drug efficacy and toxicity. With the help of multidisciplinary cross-disciplinary technology, we have developed a systematic theory and methodology to create multi-dimensional models across the differences between molecules, cells, and tissues and to realize preclinical research to evaluate target screening and test and validate therapeutic ideas.

Herbal compounding R&D platform

We will assist you in the design, screening, R&D, and market transformation of herbal medicines and innovative products based on your needs, such as the mining of ancient formulas, the development of preparations, the industrialization of previous scientific research results, and the secondary development of traditional medicines.

Herbal residue comprehensive utilization development platform

We will help you to adopt a disciplined technical approach, combined with the concept of comprehensive utilization of herbal residue, to improve the comprehensive utilization efficiency of herbal residue resources.

Herbs as cosmetic ingredients

We provide you with herbal cosmetic raw materials and combine cosmetic-related microfluidic technology and molecular biology technology to help your research and develop cosmetic plant raw materials, chemical modification and green synthesis of cosmetic raw materials, and research and development of specialty cosmetic formulations.

Herbs as feed supplements

We can help you develop natural herbs to be used in feed additives to enhance the metabolism of livestock and poultry, promote animal growth, improve fertility and productivity, and prevent and control disease, with the advantages of low cost and a wide range of effects.

Herbs as gut health beneficial ingredients

We offer solutions to help you investigate how herbs regulate gut flora dysbiosis and which active ingredients of herbs change after metabolism by the gut flora, among other vital questions. It helps to clarify the metabolism and absorption process of herbs in the body, helps to understand the mechanism of drug action and the material basis of action, and accelerates the process of modernization of herbs.

Herbs as ingredients in geriatric care

We provide you with theories and advantages based on the design of herbal healthcare products so that they can be more effective in improving the body's immune system, strengthening the physical condition of the elderly, preventing and controlling geriatric diseases, and meeting different market demands.

Research Framework and Systems

Name		Function
ADME	Absorption	Drugs are usually absorbed through the small intestine to reach the circulatory system.
	Distribution	Drugs are transported by binding to plasma proteins and are actively transported across the blood-brain barrier by the P-glycoprotein.
	Metabolism	It mainly involves the P450 family of drug-metabolizing enzymes.
	Comprehensive model	Prediction of drug half-life in vivo. Oral bioavailability of drugs.
Toxicity	Environmental toxicity (ETp)	Large-scale prediction of the environmental toxicity of chemical molecules.
	Prebiotic enrichment factor (PreBF)	Large-scale prediction of compound enrichment factors.
	Androgen/estrogen receptor binding	Predicts the binding of compounds to hormone receptors and identifies inhibitors or activators.
Target recognition	Systematic targeting	Large-scale molecular network target prediction based on chemistry, genomics, pharmacology, and systems analysis.
	Systematic toxicity target prediction	Large-scale toxicology-network target prediction based on chemistry, genomics, toxicology, and systems analysis.
	Target tissue location	Large-scale target-organ localization based on genomics and microarray analysis.
	Reverse network targeting and screening	Reverse network targeting and screening based on chemistry, genomics, pharmacology, and systems analysis.
	Drug action pattern prediction	Large-scale molecular network target mode of action prediction based on chemistry, genomics, pharmacology, and systems analysis.
Drug target optimization	Hepatitis C virus NS5B polymerase inhibitors	Application of molecular dynamics (MD) simulations to elucidate possible binding modes of mutase inhibitors.
	Respiratory syncytial virus (RSV) inhibitors	Screening and optimization of potential RSV inhibitors based on a variable selection algorithm coupled with the Random Forest method.
	Aurora kinase inhibitors	Determination of the primary structure and identification of Aurora kinase inhibitors functional groups based on 3D-QSAR and molecular Docking analysis.
Herbal medicine-related modeling	Herb pharmacology feature mapping (HPFM)	Observation of the spatial distribution of compounds based on their physicochemical characteristics to elucidate whether similar physicochemical properties have similar pharmacological activities.
	Herb repositioning	To explore the new efficacy of herbal therapeutics based on a target-disease network of herbs.
	Compound-target-disease association analysis	Based on the compound-target-disease network of drugs, to reveal the synergistic mechanism of multi-component drugs.

The platform provided by Lifeasible covers the identification of herbal formula components, metabolic pathway analysis of blood/target entry prototypes and their metabolites, network/system pharmacology and molecular docking analysis of herbs, non-target metabolome analysis of herbs, spatial metabolome analysis of herbs, and multi-component pharmacokinetic analysis of herbs. We provide platform support for herbal drug quality assessment, active ingredient screening, drug target discovery, drug mechanism of action, and other research. Please feel free to contact us for a proposal.

For research or industrial raw materials, not for personal medical use!

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