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Gene Editing in Silkworm

Gene Editing in Silkworm

Silkworms are economically important insects. The traits of silkworm species determine the yield, quality and value-added increase of follow-up products. Therefore, cultivating fine varieties has always been the goal of sericulture workers. Gene editing technology is an important means for functional gene research and biological genetic improvement. It is a powerful means to study insect genetic manipulation and gene function. In recent years, with the advancement of genome sequencing and the application of gene editing technology in silkworms, a good foundation has been laid for directional breeding and accelerated breeding progress.

Our Services for Gene Editing in Silkworm

Gene editing is an efficient and stable genetic manipulation system. A series of achievements have been made in silkworm sex determination, feeding regulation, development, resistance, and silk gland bioreactor research. Lifeasible provides silkworm gene editing services including antheraea pernyi, bombyx mori and philosamia cynthia ricini in order to provide a reference for gene function analysis, mutation model establishment, and genetic improvement of varieties in the post-genome era of the tussah silkworm.

Species Relevant traits exhibited after editing genes
Antheraea pernyi
  • Body color-associated genes
Genes related to pigment synthesis in antheraea pernyi larvae.
Pigment-binding protein genes in antheraea pernyi larvae.
Melanin biosynthesis-related genes in antheraea pernyi larvae, pupae and moths.
Editing these genes to explore the important role of antheraea pernyi body color in regulation of body temperature, protection against UV radiation damage, immunity, etc.
  • Autophagy genes
ATG5:interferes the response of the innate immune system of antheraea pernyi.
Bombyx mori
  • Immune system-related genes
BmVNCP, Bmnsd-Z, Bmnsd-2, EcR: affects the immune machinery and immune system of bombyx mori.
  • Silk protein gene
SPI51, Seroin1: affects the process of silk fibrillation or the conformational shift of silk proteins.
  • Storage protein-related genes
BmSP2: affects growth and reproduction, metamorphosis development and immune resistance in bombyx mori.
Philosamia cynthia ricini
  • Ferritin-related genes
  • Reproduction-related genes
  • Hormone synthesis-related genes
  • Growth and development-related genes

Our Methods for Gene Editing in Silkworm

Lifeasible offers zinc-finger nucleases (ZFNs), transcription activator-like effector nucleases (TALEN) and CRISPR/Cas9 to edit specific genes in antheraea pernyi, bombyx mori and philosamia cynthia ricini to conduct functional analysis of genes, establishment of mutation models, and genetic improvement of varieties.

Advantages

We use advanced gene editing methods to edit specific genes, analyze the functions of related genes, and explore the genetic and physiological mechanisms of antheraea pernyi, bombyx mori and philosamia cynthia ricini. we can edit the immune system-related genes, reproduction-related genes, and growth and development-related genes help to study these silkworms.

Lifeasible provides gene editing services for three silkworms including antheraea pernyi, bombyx mori and philosamia cynthia ricini by ZFNs, TALEN and CRISPR/Cas9 to study the development of these silkworms. If you are interested in our services or if you have any questions, please click online inquiry for more detailed information.

Our Services are for Research Use Only. Not for Clinical Use!
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