Thiacloprid is a neonicotinoid insecticide that acts as a selective agonist at insect nicotinic acetylcholine receptors (nAChRs) with IC50 values of 2.7 and 860 nM for Drosophila nAChRs and M10 mouse fibroblast cells expressing α4β2 subunit-containing nAChRs, respectively.