Liposome Lamellarity Analysis

Lifeasible provides liposome characterization services. We offer characterization services, including encapsulation efficiency, physicochemical properties, composition, and stability studies, all of which are critical to developing liposomes.

About Liposome Lamellarity

Among structural properties, lamellarity, the number of concentric lipid bilayers in a liposome, is one of the most relevant properties. Laminarity determines the stability of liposomes, the number of molecules that can be encapsulated, the release kinetics, and the properties of liposomes when interacting with cells. In addition, it determines liposomes' overall mechanical and dielectric properties, which are related to their interaction with cells.

Figure 1. Lamellarity distribution. (Di et al., 2021)

Generally, the lamellarity can be determined using techniques such as NMR, X-ray small angle scattering, and fluorescence spectroscopy. These techniques provide an average lamellarity of the liposome population. Laminarities can also be determined at the level of individual liposomes by considering imaging techniques such as cryo-electron microscopy, cryo-fracture electron microscopy, and light microscopy or mechanical techniques such as micropipette aspiration. Recently, atomic force microscopy (AFM) and force spectroscopy measurements have also been developed.

Our Services

Lifeasible has extensive experience in analyzing small molecules encapsulated into liposomes and a range of other liposomes. Based on our team of experienced scientists, experts, and state-of-the-art laboratories, along with state-of-the-art technology and industry expertise, we are committed to bringing you the best possible customer experience and are constantly updating our services to ensure that we can be of great assistance to our customers now and in the future.

Services Content

• Liposome laminar characterization testing

Determination of average lamellarity by NMR, X-ray small angle scattering, and fluorescence spectroscopy; determination of lamellarity of individual liposomes using cryo-electron microscopy techniques.

• Liposome lamellar analysis solutions

Our experts can provide customized liposome lamellar analysis solutions for your prepared liposomes and provide the most reliable and consistent data reporting.

In addition to the services listed above, you can consult our staff to provide additional services not listed above. As a professional technical testing platform, we can provide you with other liposome-related services in addition to sample testing.

Our Advantages

• We provide a full range of integrated services, from small molecule wrapping customization of liposomes to physicochemical property testing of liposomes, stability studies, etc.
• Professional experimental team, our experimental staff, including master's degree, Ph.D. and other high-end technical personnel, can provide professional advice and guidance to our client's projects.
• We specialize in providing one-on-one service for our client's projects, and the whole process is efficient, which greatly saves our clients' time. At the same time, we also provide real-time project reports, so you can keep an eye on the project's progress and data reports.
• We can serve you satisfactorily, and all of our staff are trained to be very enthusiastic and have a great work ethic to make you feel very comfortable.

If you are interested in our services and products, please do not hesitate to contact us anytime.