Product Name
Lycorine hydrochloride
Description
Lycorine hydrochloride is the main active ingredient of the herbal medicine derived from Lycoris radiata (L’Her.) Herb. and is also a melanoma vasculogenic inhibitor and has anti-tumor activity. Lycorine hydrochloride effectively inhibits mitotic proliferation of Hey1B cells (IC50 of 1.2 μM).
Structural Formula
Lycorine hydrochloride
Solubility
DMSO : 25 mg/mL, H2O : 16.67 mg/mL
Source
Plants >Amaryllidaceae > Lycoris radiata(L’Her.) Herb.
Storage
4℃, sealed storage, away from moisture
Shipping
Room temperature in continental US; may vary elsewhere.
SMILES
O[C@@H]1[C@@H](O)C=C(CC2)[C@@]3([H])N2CC4=C([C@@]31[H])C=C(OCO5)C5=C4.Cl
In Vivo
Lycorine hydrochloride (0-15 μg; subcutaneous injection; for 14 days; BALB/C nude mice) treatment has an inhibitory effect on melanoma cell-mediated tumor vasculogenic mimicry. Animal Model:6- to 8-week-old BALB/C nude mice Dosage:0 μg, 7.5 μg, 15 μg Administration:Subcutaneous injection; for 14 days Result:Showed an inhibitory effect on melanoma cell-mediated tumor vasculogenic mimicry.
In Vitro
Lycorine hydrochloride (0-25 μM; 48 hours; C8161 cells) treatment markedly suppresses the expression of vascular endothelial (VE)-cadherin in a dose-dependent manner and also slightly diminishes the expression of Sema4D in C8161 cells. However, the expression of the other six genes is not affected.Lycorine hydrochloride (0-25 μM; 48 hours; C8161 cells) treatment markedly reduces VE-cadherin protein levels in C8161 cells in a dose-dependent fashion.
Datasheet 
