Description
Retrorsine is a naturally occurring toxic pyrrolizidine alkaloid. Retrorsine can bind with DNA and inhibits the proliferative capacity of hepatocytes. Retrorsine can be used for the research of hepatocellular injury.
Structural Formula
Retrorsine
Solubility
DMSO : 100 mg/mL
Source
Plants >Leguminosae > Erinacea anthyllisLink >Plants >Compositae
Storage
-20℃, protect from light
Shipping
Room temperature in continental US; may vary elsewhere.
SMILES
O=C(O[C@]1([H])CCN2[C@]1([H])C(COC([C@](CO)(O)[C@H](C)C/3)=O)=CC2)C3=C/C
In Vivo
Retrorsine (30 mg/kg; i.p.; twice) impairs liver regeneration in the PBL model not only by an S or G2/M phase block, but also by a block located before the G1/S transition of the cell cycle.Animal Model:Male Wistar rats (180±20 g), portal branch ligation (PBL) modelDosage:30 mg/kgAdministration:Intraperitoneal injection, twice, separated by 2-week intervalResult:Strongly impaired the liver weight gain, protein and DNA synthesis as well as induction of cell cycle related proteins in the regenerating lobes after PBL.
In Vitro
Retrorsine (60-240 μM; 24 hours) significantly reduces HSEC-CYP3A4 cells viability and GSH levels, and increases formation of pyrrole-protein adducts.
Datasheet 
