Product Name
Sinococuline
Description
Sinococuline is a potent anti-dengue agent that is effective against all four serotypes of dengue virus (DENV). Sinococuline is also an effective tumor cell growth inhibitor.
Structural Formula
Sinococuline
Source
Plants >Menispermaceae > Stephania japonica(Thunb.) Miers
Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Shipping
Room temperature in continental US; may vary elsewhere.
SMILES
COC1=C([C@]([H])(C2)NCC3)[C@]3(C4=C2C=CC(OC)=C4O)C[C@H](O)[C@@H]1O
In Vivo
Sinococuline (0.5-2.0 mg/kg/day; i.p. twice a day for 5 days) decreases the morbidity and increases the survival of severely DENV-infected AG129 mice, with no body weight change.
In Vitro
Sinococuline (0.5-5.0 μg/mL; 6 days) inhibits the non-structural protein-1 (NS1) release by DENV-2 infected Vero cells.Sinococuline (0-40 μg/mL; 48 h) inhibits pan-DENV infection in Vero cells, with IC50s of 0.2, 0.08, 0.17, and 0.1 μg/mL for DENV-1, DENV-2, DENV-3, and DENV-4, respectively.
Datasheet 
