Synonyms
(-)-Anagyrine; Monolupine; Rhombinine
Description
Anagyrine ((-)-Anagyrine) is a quinolizidine alkaloid that has been found in Lupinus albus. Anagyrine binds to muscarinic and nicotinic acetylcholine receptors with IC50 values of 132 and 2096 µM respectively. Anagyrine is a potent and effective desensitizer of nAChR, and Anagyrine can directly, without metabolism, desensitize nAChR.
Structural Formula
Anagyrine
Source
Plants >Leguminosae > Lupinus albusLinn.
Storage
4℃, protect from light
Shipping
Room temperature in continental US; may vary elsewhere.
SMILES
O=C1N2C([C@]3([H])C[C@]([C@]4([H])N(CCCC4)C3)([H])C2)=CC=C1
In Vitro
Anagyrine acts as a partial agonist in both cell lines with EC50 values of 4.2 and 231 μM in SH-SY5Y and TE-671 cells, respectively. Anagyrine is a desensitizer of nAChR with DC50 values of 6.9 and 139 μM in SH-SY5Y and TE-671 cells, respectively.
Datasheet 
