Product Name
Villocarine A
Description
Villocarine A is a natural vasorelaxant indole alkaloid.
Structural Formula
Villocarine A
Source
Plants >Rubiaceae > Uncaria rhynchophylla(Miq.) Miq. ex Havil.
Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Shipping
Room temperature in continental US; may vary elsewhere.
SMILES
COC(/C([C@H]1C[C@]2([H])C3=C(CCN2C/C1=C/C)C4=CC=CC=C4N3)=C/OC)=O
In Vitro
Villocarine A exhibited excellent activity during the initial stage, within 10-30 min after injection, with potent vasorelaxant effects observed at 30 μM against PE-mediated contraction in a rat aorta. Villocarine A exhibited a moderate level of inhibition at 30 μM against PE and 1 μM-induced contraction of the aortic rings in the presence of nicardipine (1 μM) in a Ca2+-free medium.
Datasheet 
