Product Name
Ellipticine hydrochloride
Synonyms
NSC 71795 hydrochloride
Description
Ellipticine (NSC 71795) hydrochloride is a potent antineoplastic agent; inhibits DNA topoisomerase II activities.
Structural Formula
Ellipticine hydrochloride
Solubility
DMSO : 5.8 mg/mL(20.51 mM;Need ultrasonic and warming) H2O : (insoluble)
Source
Plants >Apocynaceae > Amsonia elliptica (Thunberg ex Murray) Roemer & Schultes
Storage
4℃, sealed storage, away from moisture
Shipping
Room temperature in continental US; may vary elsewhere.
SMILES
CC1=C(C=NC=C2)C2=C(C)C(N3)=C1C4=C3C=CC=C4.Cl
In Vivo
Ellipticine (NSC 71795) treatment results in ellipticine-derived DNA adduct generation in several healthy organs (liver, kidney, lung, spleen, breast, heart and brain) and in DNA of mammary adenocarcinoma. The levels of Ellipticine (NSC 71795)-derived DNA adducts generated in these adenocarcinomas are almost 2-fold higher than in normal healthy mammary tissue. The induced expression of cytochrome b5 protein in liver of rats treated with Ellipticine (NSC 71795) suggests that cytochrome b5 may modulate the CYP-mediated bioactivation and detoxification of Ellipticine (NSC 71795).
In Vitro
Ellipticine (NSC 71795) is a potent antineoplastic agent exhibiting the multimodal mechanism of its action. The mechanisms of Ellipticine (NSC 71795) antitumor, mutagenic and cytotoxic activities are suggested to be intercalation into DNA and inhibition of DNA topoisomerase II activity. Another mode of Ellipticine (NSC 71795) action is the formation of covalent DNA adducts mediated by its oxidation with cytochromes P450 (CYP) and peroxidases.
Datasheet 
