Product Name
Rauwolscine hydrochloride
Synonyms
α-Yohimbine hydrochloride; Corynanthidine hydrochloride; Isoyohimbine hydrochloride
Description
Rauwolscine hydrochloride is a potent and specific α2 adrenergic receptor antagonist with a Ki of 12 nM.
Structural Formula
Rauwolscine hydrochloride
Solubility
DMSO : 6 mg/mL(15.35 mM;Need ultrasonic) H2O : 5 mg/mL(12.79 mM;Need ultrasonic)
Source
Plants >other families
Storage
4℃, sealed storage, away from moisture
Shipping
Room temperature in continental US; may vary elsewhere.
SMILES
[H]Cl.[H][C@]12C(NC3=C4C=CC=C3)=C4CCN1C[C@@]5([H])CC[C@H](O)[C@@H](C(OC)=O)[C@]5(C2)[H]
In Vitro
[3H]Rauwolscine binding to α2 adrenergic receptor is reversible, stcreospccific, and saturable. [3H]Rauwolscine specifically labels both the high and low affinity states of the α2 adrenergic receptor in brain membranes. [3H]Rauwolscine also behaves as a 5-HT1A receptor agonist and this conclusion is compatible with earlier functional studies, indicating that rauwolscine (as well as yohimbine) has agonistic properties at the level of 5-HT autoreceptors.
Datasheet 
