Product Name
Phosphoramidon Disodium
Description
Phosphoramidon Disodium, a microbial metabolite, is a specific metalloprotease thermolysin inhibitor with an IC50 of 0.4 μg/mL. Phosphoramidon Disodium also inhibits endothelin-converting enzyme (ECE), neutral endopeptidase (NEP), and angiotensin-converting enzyme (ACE) with IC50 values of 3.5, 0.034, and 78 μM, respectively.
Structural Formula
Phosphoramidon Disodium
Solubility
H2O : 100 mg/mL(170.22 mM;Need ultrasonic) DMSO : 100 mg/mL(170.22 mM;Need ultrasonic)
Source
Streptomyces tanashiensis
Storage
4℃, sealed storage, away from moisture
Shipping
Room temperature in continental US; may vary elsewhere.
SMILES
O=C([C@@H](NC([C@@H](NP(O[C@H]1[C@H](O)[C@H](O)[C@@H](O)[C@@H](O1)C)(O[Na])=O)CC(C)C)=O)CC2=CNC3=CC=CC=C23)O[Na]
In Vivo
Phosphoramidon (0.25 mg/kg per min; i.v.) suppresses the hypertensive effect of big endothelin-1 in rats.Phosphoramidon (1-30 mg/kg; i.v.; once) blocks the pressor activity of porcine big endothelin-1-(1-39) in rats.
In Vitro
Phosphoramidon (1-500 μM; 30 min) inhibits ET-converting enzyme (ECE) activity in a dose-dependent manner in solubilized rabbit lung membranes.
Datasheet 
