Product Name
Endomorphin 1
Description
Endomorphin 1, a high affinity, highly selective agonist of the μ-opioid receptor (Ki: 1.11 nM), displays reasonable affinities for kappa3 binding sites, with Ki value between 20 and 30 nM. Endomorphin 1 has antinociceptive properties.
Structural Formula
Endomorphin 1
Solubility
H2O : 25 mg/mL(40.94 mM;Need ultrasonic)
Storage
Sealed storage, away from moisture and light, under nitrogen
Shipping
Room temperature in continental US; may vary elsewhere.
In Vivo
Endomorphin 1 (i.c.v.) shows antinociceptive properties in mice, with an ED50 value of 6.16 nM.Endomorphin 1 (50 μg/kg, i.v.) alleviates myocardial ischemia/reperfusion injury (MIRI) by inhibiting the inflammatory response.
In Vitro
Endomorphin 1 inhibits Forskolin (HY-15371) (1 μM) stimulated cyclic AMP formation with a pIC50 value of 8.03 in In CHOμ cells.Endomorphin 1 (1-10 μM) increases interleukin-8 secretion in Caco-2 cells.Endomorphin 1 (1 μM) inhibits excitatory transmission in adult rat substantia gelatinosa neurons.
Datasheet 
