Product Name
Manzamine A hydrochloride
Synonyms
Keramamine A hydrochloride
Description
Manzamine A hydrochloride, an orally active beta-carboline alkaloid, inhibits specifically GSK-3β and CDK-5 with IC50s of 10.2 μM and 1.5 μM, respectively. Manzamine A hydrochloride targets vacuolar ATPases and inhibits autophagy in pancreatic cancer cells. Manzamine A hydrochloride has antimalarial and anticancer activities. Manzamine A hydrochloride also shows potent activity against HSV-1.
Structural Formula
Manzamine A hydrochloride
Solubility
DMSO : 5.88 mg/mL(10.05 mM;Need ultrasonic)
Storage
4℃, sealed storage, away from moisture and light
Shipping
Room temperature in continental US; may vary elsewhere.
SMILES
O[C@]1(CC/C=C\CCCC2)[C@@]3([H])[C@@](C[C@@]4([H])N3CCCC/C=C\4)(C[N@@]2CC5)[C@]5([H])C(C6=C(NC7=CC=CC=C87)C8=CC=N6)=C1.Cl
In Vivo
Manzamine A (50 and 100 mol/kg, p.o. or i.p.) hydrochloride inhibits the growth of the rodent malaria parasite Plasmodium berghei in infected mice. Manzamine A (8 mg/kg, i.p., daily for 8 consecutive days) hydrochloride prolongs the survival of SW mice to 20 days.
In Vitro
Manzamine A (5-50 µM, 18 h) hydrochloride decreases tau phosphorylation, measured with ELISA.Manzamine A (10 µM) hydrochloride inhibits yeast S. cerevisiae growth by 30%. Manzamine A hydrochloride displays a few enlarged vacuoles in yeast. Manzamine A (2.5-10 µM, 24 h) hydrochloride increases acidity in pancreatic cancer cells and non-malignant Vero cells. Manzamine A (1 µM, 24 h) hydrochloride inhibits HSV-1 infection in SIRC cells.Manzamine A hydrochloride shows antimalarial activity with an IC50 of 8.0 nM (D6 clone) and 11 nM (W2 clone).
Datasheet 
