Product Name
L-(+)-Abrine
Synonyms
L-Abrine; L-N-Methyltryptophan; N-α-Methyl-L-tryptophan
Description
L-(+)-Abrine, a lethal albumin found in Abrus precatorius seeds, is an acute toxic alkaloid and chemical marker for abrin.
Structural Formula
L-(+)-Abrine
Solubility
H2O : 1.85 mg/mL(8.48 mM;ultrasonic and adjust pH to 10 with NaOH)
Source
Plants >Leguminosae > Abrus precatoriusLinn.
Shipping
Room temperature in continental US; may vary elsewhere.
SMILES
O=C(O)[C@H](CC1=CNC2=CC=CC=C12)NC
In Vivo
Abrin is a toxic protein found in the jequirity seed. L-(+)-Abrine (L-Abrine) is also found in the jequirity seed and can be used as a biomarker for abrin exposure. An animal study is designed to monitor the excretion and recovery of L-(+)-Abrine in 20 rats. The animals are exposed to one of three concentrations of L-(+)-Abrine, a single high concentration of L-tryptophan, or no agent (control). The low L-(+)-Abrine dose corresponds to 0.63 LD50 i.p. abrin in mice, assuming a concentration ratio of 1:4 of abrin to L-(+)-Abrine and an LD50 for abrin of 20 μg/kg. The mid and high L-(+)-Abrine (250 and 400 μg/kg) doses are included to ensure that the target analyte can be detected and tracked over the course of the experiment.
In Vitro
L-(+)-Abrine is a marker for abrin poisoning. A strong indication for abrin poisoning is the presence of the chemical maker L-(+)-Abrine, which can survive metabolism in significant amounts making it detectable in human urine.
Datasheet 
