Description
Hirsutine, an indole alkaloid of Uncaria rhynchophylla, exhibits anti-cancer activity. Hirsutine induces apoptosis and is a potent Dengue virus inhibitor exhibiting low cytotoxicity.
Structural Formula
Hirsutine
Solubility
DMSO : 100 mg/mL(271.39 mM;Need ultrasonic)
Source
Plants >Rubiaceae > Uncaria rhynchophylla(Miq.) Miq. ex Havil.
Shipping
Room temperature in continental US; may vary elsewhere.
SMILES
O=C(OC)/C([C@H]([C@H](CN1CC2)CC)C[C@]1([H])C3=C2C(C=CC=C4)=C4N3)=C/OC
In Vivo
Hirsutine induces mPTP-dependent apoptosis through ROCK1/PTEN/PI3K/GSK3β pathway in human lung cancer cells.
In Vitro
Hirsutine remarkably reduces the viability of MCF-7 and MDA-MB-231 cells in a time- and dose-dependent manner with IC50 values of 447.79 and 179.06 μM, respectively. In the MDA-MB-231 cells, Hirsutine induces apoptosis and depolarization of MMP, releases Cyt C from mitochondria, and activates caspase 9 and caspase 3.
Datasheet 