Synonyms
Indoline-2,3-dione
Description
Isatin (Indoline-2,3-dione) is a potent inhibitor of monoamine oxidase (MAO) with an IC50 of 3 μM. Also binds to central benzodiazepine receptors (IC50 against clonazepam, 123 μM). Also acts as an antagonist of both atrial natriuretic peptide stimulated and nitric oxide-stimulated guanylate cyclase activity. Shows effect on the serotonergic system.
Structural Formula
Isatin
Solubility
DMSO : 110 mg/mL(747.64 mM;Need ultrasonic) H2O : (insoluble)
Source
Plants >other families
Shipping
Room temperature in continental US; may vary elsewhere.
SMILES
O=C1NC2=C(C=CC=C2)C1=O
In Vivo
A single dose of isatin (80 mg/kg) has a rapid effect on the serotonergic system in the hypothalamus. Isatin significantly increases 5-HT concentrations in the hypothalamus and cortex but did not significantly alter 5-HIAA concentrations.
In Vitro
In dopaminergic SH-SY5Y cells isatin (1-400 μM) induces cell death in dose- and time dependent manner. This death occurred as a continuum of survival, apoptosis and necrosis.
Datasheet 
