Description
Flazin is a non-enzymatic protein glycation inhibitor, also inhibits peroxynitrite (ONOO-), with an IC50 value of 85.31 μM for bovine serum albumin (BSA) glycation and an EC50 value of 71.99 μM for ONOO-. Flazin can be used for researching diabetes and neuronal disorders. Flazin also can used as a lipid droplet (LD) regulator against lipid disorders, and a xanthine oxidase (XOD) inhibitor.
Structural Formula
Flazin
Source
Plants >Simaroubaceae > Brucea javanica(L.) Merr.
Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Shipping
Room temperature in continental US; may vary elsewhere.
SMILES
O=C(C1=CC2=C(C(C3=CC=C(CO)O3)=N1)NC4=C2C=CC=C4)O
In Vitro
Flazin significantly decreases cellular triglyceride (TG) by 12.0-22.4% compared with modeling groups and improved the TG and free fatty acid profile. Flazin efficiently reduces both cellular neutral lipid content by 17.4-53.9% and lipid droplets size by 10.0-35.3%. Flazin exhibits xanthine oxidase inhibitory with an IC50 of 0.51 mM.
Datasheet 
