Product Name
Picrasidine Q
Description
Picrasidine Q, an alkaloid component extracted from Angelica keiskei species, has the capacity of anti-cell transformation and anti-cancer. Picrasidine Q induces cell apoptosis and G1 phase arrest in human esophageal cancer cell lines, and directly inhibits FGFR2 kinase activity.
Source
Plants >other families
Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Shipping
Room temperature in continental US; may vary elsewhere.
SMILES
O=C1C(OC)=C(C2=NC=CC3=C2N1C4=CC=CC=C34)O
In Vitro
Picrasidine Q (0~60 μM; 3 hours; ESCC cells) suppresses downstream signaling of FGFR2 in ESCC cells.Picrasidine Q (0~60 μM; 48 and 72 hours; ESCC cells) induces cell cycle arrest and apoptosis.Picrasidine Q (0~60 μM; 24~72 hours; ESCC cells) suppresses the growth of ESCC cells.Picrasidine Q (0~60 μM; 30 minutes; JB6Cl41 cells) inhibits proliferation by inhibition of G1/S cell cycle transition.Picrasidine Q (12.5, 25 or 50 μM) can inhibit the FGFR2 kinase activity in a dose-dependent manner.
Datasheet 
