Description
Meleagrin is a roquefortine C-derived alkaloid produced by fungi of the genus Penicillium and has antimicrobial and anti-proliferative activities. Meleagrin is a class of FabI inhibitor. Meleagrin is a lead c-Met inhibitory entity useful for the control of c-Met-dependent metastatic and invasive breast malignancies.
Structural Formula
Meleagrin
Source
marine fungus Emericella dentata Nq45
Storage
-20℃, protect from light
Shipping
Room temperature in continental US; may vary elsewhere.
SMILES
O=C1N[C@@]23N(OC)C4=C(C=CC=C4)[C@]2(C(C)(C)C=C)C=C(O)C(N3/C1=C/C5=CN=CN5)=O
In Vivo
Meleagrin potently suppresses the invasive triple negative breast tumor cell growth in an orthotopic athymic nude mice model.
In Vitro
Meleagrin inhibits the growth of the human breast cancer cell lines MDA-MB-231, MDA-468, BT-474, SK BR-3, MCF7 and MCF7-dox.Meleagrin causes a dose-dependent inhibition of HGF-induced cell migration, and invasion of breast cancer cell lines.
Datasheet 
