Description
Mahanimbine is an orally active alkaloid from Murraya koenigii. Mahanimbine inhibits progression of high-fat diet (HFD)-induced metabolic complications in mice.
Structural Formula
Mahanimbine
Source
Plants >Rutaceae >Murraya koenigii (L.) Spreng >Plants >Rutaceae > Murraya exotica L. Mant.
Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Shipping
Room temperature in continental US; may vary elsewhere.
SMILES
C/C(C)=C\CC[C@]1(C)OC(C(C)=CC2=C3NC4=C2C=CC=C4)=C3C=C1
In Vivo
Mahanimbine (2-4 mg/kg; p.o.; daily for 12 weeks) prevents HFD-induced weight gain in mice (male and female).Mahanimbine prevented HFD-induced hyperlipidemia and fat accumulation in adipose tissue and liver along with the restricted progression of systemic inflammation and oxidative stress.Mahanimbine treatment improves glucose clearance and upregulates the expression of insulin responsive genes in liver and adipose tissue.
Datasheet 
