Product Name
Guanfu base I
Description
Guanfu base I (Acorine) is an active metabolite of Guanfu base A, isolated from Aconitum coreanum, and has a potent anti-arrhythmic effect.
Structural Formula
Guanfu base I
Source
Plants >Ranunculaceae > Aconitum coreanum(Lévl.) Rapaics
Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Shipping
Room temperature in continental US; may vary elsewhere.
SMILES
O[C@@]12C3[C@]45[C@@]([C@@H]6O)([H])C1(CC([C@@]6([H])[C@H]2O)=C)C[C@@]7([H])[C@]4([H])[C@@](C)(C[C@H](OC(C)=O)C5)C[N@]37
In Vivo
The pharmacokinetics of Guanfu base I in Sprague-Dawley rats is examined. The method is linear in the 0.05-20 μg/mL concentration range. The recovery of Guanfu base I is more than 80%. The intraday and interday precision, expressed as the relative standard deviation, is generally good. After intravenous injection dosing, plasma Guanfu base I concentration declined in a bi-phasic manner with a terminal elimination half-life of 2.49 hours. The total plasma clearance value is 1.46 L/h/kg. After oral dosing, the plasma Guanfu base I concentration reached a maximum within 0.5 hour. The absolute bioavailability of Guanfu base I is 71.31%.
Datasheet 
