Product Name
Vinorelbine ditartrate
Synonyms
KW-2307; Nor-5'-anhydrovinblastine ditartrate
Description
Vinorelbine (ditartrate) is an anti-mitotic agent which inhibits the proliferation of Hela cells with IC50 of 1.25 nM.
Structural Formula
Vinorelbine ditartrate
Solubility
DMSO : ≥ 100 mg/mL(92.67 mM ) H2O : ≥ 100 mg/mL(92.67 mM )
Source
Plants >Apocynaceae > Catharanthus roseus(L.) G. Don
Storage
4℃, sealed storage, away from moisture and light
Shipping
Room temperature in continental US; may vary elsewhere.
SMILES
CC[C@@]1(C=CCN2CC3)[C@@]2([H])[C@@]3(C(C=C([C@@](C4=C5C(C=CC=C6)=C6N4)(CC(C=C(CC)C7)([H])CN7C5)C(OC)=O)C(OC)=C8)=C8N9C)[C@]9([H])[C@](C(OC)=O)(O)[C@@H]1OC(C)=O.O=C(O)[C@H](O)[C@@H](O)C(O)=O.O=C(O)[C@H](O)[C@@H](O)C(O)=O
In Vitro
Vinorelbine (0.5-5 nM) ditartrate inhibits cell proliferation by 50% (IC50) at concentrations of 1.25 nM. At a concentration of 8 nM, no cells are in anaphase. Vinorelbine ditartrate time-dependently induces the p53 and p21WAFI/CIP1 expression in androgen-dependent (AD) and- independent (AI) prostate cancer cell lines. Vinorelbine ditartrate stimulates reporter genes in a concentration-dependent manner.
Datasheet 
