Product Name
3,3'-Diindolylmethane
Synonyms
DIM; Arundine; HB 236
Description
3,3'-Diindolylmethane is a strong, pure androgen receptor (AR) antagonist.
Structural Formula
3,3'-Diindolylmethane
Solubility
DMSO : ≥ 100 mg/mL(405.99 mM )
Source
Plants >other families
Storage
4℃, protect from light, stored under nitrogen
Shipping
Room temperature in continental US; may vary elsewhere.
SMILES
C1(CC2=CNC3=C2C=CC=C3)=CNC4=C1C=CC=C4
In Vivo
Mice are randomized into two groups and are treated daily s.c. with either vehicle or 3,3'-Diindolylmethane (10 mg/kg) for 30 days. Tumor volume and the weight of mice are recorded once every 3 days using calipers. 3,3'-Diindolylmethane (DIM) treatment resulted in a marked inhibition of SNU-484 xenograft tumor growth. Notably, the body weight of mice from both groups did not significantly differ from the vehicle control following 30 days of drug exposure, suggesting that 3,3'-Diindolylmethane has no severe toxicity to the mice. Taken together, these findings demonstrate that 3,3'-Diindolylmethane administration significantly inhibited SNU-484 xenograft growthin vivo mediated by the inactivation of YAP.
In Vitro
3,3'-Diindolylmethane (DIM) is a strong antagonist of androgen receptor (AR) function but exhibits less than obvious structural similarity to the endogenous AR ligand, dihydrotestosterone (DHT). 3,3'-Diindolylmethane is a major digestive product of indole-3-carbinol, a potential anticancer component of cruciferous vegetables. 3,3'-Diindolylmethane exhibits potent antiproliferative and antiandrogenic properties in androgen-dependent human prostate cancer cells. 3,3'-Diindolylmethane suppresses cell proliferation of LNCaP cells and inhibits DHT stimulation of DNA synthesis.
Datasheet 
