Description
Cycleanine is a potent vascular selective Calcium antagonist. Cycleanine has analgesic, muscle relaxant and anti-inflammatory activities. Cycleanine has potential for anti-ovarian cancer acting through the apoptosis pathway.
Structural Formula
Cycleanine
Solubility
DMSO : 5 mg/mL(8.03 mM;ultrasonic and warming and heat to 60°C)
Source
Plants >Menispermaceae > Cissampelos pareira
Storage
4℃, sealed storage, away from moisture and light
Shipping
Room temperature in continental US; may vary elsewhere.
SMILES
COC1=C(OC2=CC=C(C[C@](N(CC3)C)([H])C4=C3C=C5OC)C=C2)C([C@@](N6C)([H])CC7=CC=C(OC4=C5OC)C=C7)=C(CC6)C=C1OC
In Vivo
Cycleanine inhibits the KCl-induced contraction of rabbit aortic rings with an IC50 of 0.8 nM.
In Vitro
Cycleanine inhibits L-type Ca-current (ICaL) of single rat ventricular cardiomyocytes in a voltage- and frequency-dependent manner.Cycleanine shows modestly less potency against human OSE cells (normal) than the cancer cells.Cycleanine (20 μM; 48 hours) exhibits cytotoxicity for Ovcar-8, A2780, Igrov-1, and Ovcar-4 cell lines with IC50s ranging from 7 to 14 μM.Cycleanine (20 μM; 24 hours) results in significant PARP cleavage (a marker of apoptosis).Cycleanine (20 μM; 48 hours) causes a significant increase of the population of both early and late apoptotic cells.
Datasheet 
