Description
Colcemid (Demecolcine) is a potent mitotic inhibitor with an IC50 value of 2.4 μM for inhibition of tubulin polymerization. Colcemid (Demecolcine) can interact with tubulin dimers to induce anti-mitotic action and inhibit microtubule growth. Colcemid (Demecolcine) can be used for inflammatory disorders and cancer research.
Structural Formula
Colcemid
Solubility
DMSO : 25 mg/mL, H2O : 5 mg/mL
Source
Plants >other families
Shipping
Room temperature in continental US; may vary elsewhere.
SMILES
O=C1C=C2[C@@H](NC)CCC3=CC(OC)=C(OC)C(OC)=C3C2=CC=C1OC
In Vivo
Colcemid (Demecolcine) (0.3 mg/kg for intraperitoneal injection) increases the incidence of metaphase II hypoploidy in demecolcine treated mice.
In Vitro
Colcemid (Demecolcine) (0.1-0.25 μg/ml, 1 h) reduces the the hypoploidy frequencies in metaphase II complements of mouse, rat and frog spermatocytes.
Datasheet 
