Product Name
(-)-Securinine
Description
(-)-Securinine is plant-derived alkaloid and also a GABAA receptor antagonist.
Structural Formula
(-)-Securinine
Solubility
DMSO : 2 mg/mL(9.21 mM;Need ultrasonic)
Source
Plants >Euphorbiaceae > Flueggea suffruticosa(Pall.) Baill.
Shipping
Room temperature in continental US; may vary elsewhere.
SMILES
O=C(O1)C=C2[C@@]13[C@](CCCC4)([H])N4[C@](C3)([H])C=C2
In Vivo
In this tumor model, tumor growth is significantly impaired with (-)-Securinine treatment indicating that (-)-Securinine has potential as an Acute Myeloid Leukemia (AML) therapeutic. (-)-Securinine treated mice (n=5 mice, bilateral tumors), exhibit an average of more than 75% smaller tumors than vehicle treated mice at the end of the study period.
In Vitro
(-)-Securinine is a major plant-derived alkaloid and also a GABAA receptor antagonist. (-)-Securinine is significantly potent on HeLa cells growth inhibition with IC50 values of 7.02±0.52 μg/mL (32.3 μM). (-)-Securinine induces apoptosis in a dose-dependent manner in the tested cells, increases the percentage of ROS positive cells and depolarized cells as well as stimulates the activity of ERK1/2, caspase-9 and -3/7. (-)-Securinine also induces cell cycle arrest in S phase. Real-time PCR analysis shows high expression of tumor necrosis factor receptor superfamily (TNFRSF) genes in the cells stimulated with (-)-Securinine.
Datasheet 
