Synonyms
(S)-Anabasine; (+)-Anabasine
Description
Anabasine ((S)-Anabasine) is an alkaloid that found as a minor component in tobacco (Nicotiana). Anabasine is a botanical pesticide nicotine, acts as a full agonist of nicotinic acetylcholine receptors (nAChRs). Anabasine induces depolarization of TE671 cells endogenously expressing human fetal muscle-type nAChRs (EC50=0.7 µM).
Structural Formula
Anabasine
Solubility
DMSO : 100 mg/mL(616.41 mM;Need ultrasonic)
Source
Plants >Solanaceae > Nicotiana tabacumL.
Storage
4℃, protect from light
IC50 & Target
Microbial Metabolite
Shipping
Room temperature in continental US; may vary elsewhere.
SMILES
C1([C@H]2NCCCC2)=CC=CN=C1
In Vivo
Anabasine significantly reverses the impairment at the 0.2 mg/kg (p<0.05) and 2 mg/kg doses (p<0.025). Anabasine does not have any significant effects on response latency when administered alone. The 0.06 mg/kg Anabasine dose, in fact, significantly (p<0.05) exacerbates the dizocilpine-induced impairment. None of these Anabasine doses affects choice accuracy on their own. Individual dose comparisons show that the 0.06 mg/kg Anabasine dose plus dizocilpine (6.7±2.6) causes a significant (p<0.05) increase in non-response trials compare with dizocilpine alone (2.1±0.8).
Datasheet 
