Aloperine

Name: Aloperine
SKU: ALK-0073

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Cat#

ALK-0073

Product Name

Aloperine

CAS No.

56293-29-9

Description

Aloperine is an alkaloid in sophora plants such as Sophora alopecuroides L, which has shown anti-cancer, anti-inflammatory and anti-virus properties.Aloperine is widely used to treat patients with allergic contact dermatitis eczema and other skin inflammation in China. Aloperine induces apoptosis and autophagy in HL-60 cells.

Structural Formula

Aloperine

232.36

C15H24N2

Purity

>98.0%

Appearance

Solid

Solubility

DMSO : 5.56 mg/mL(23.93 mM;ultrasonic and warming and heat to 60°C)

Source

Plants >Leguminosae > Sophora alopecuroidesL

Storage

4℃, sealed storage, away from moisture

IC50 & Target

Microbial Metabolite

Shipping

Room temperature in continental US; may vary elsewhere.

SMILES

[H][C@]1(C2)[C@](CCCC3)([H])N3C[C@]2([H])[C@@]4([H])C(CCCN4)=C1

In Vitro

Aloperine (1-20 μM; 24 hours) gives growth-inhibitory IC50 values in cancer cells ranges from 0.04 to 1.36 mM, the IC50 values in HL-60, U937, K562, EC109, A549 and HepG2 cells are 0.04, 0.27, 0.36, 1.11, 1.18 and 1.36 mM,respectively.Aloperine (1-20 μM; 24 hours) induces apoptosis and decreases bcl-2 expression in HL-60 cells.Aloperine (20-100 μM; 18 hours) induces autophagy and formation of acidic vacuole in HL-60 cells.

Datasheet

For research or industrial raw materials, not for personal medical use!

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