Product Name
Xestospongin C
Synonyms
(-)-Xestospongin C
Description
Xestospongin C ((-)-Xestospongin C) is a selective, reversible inositol 1,4,5-trisphosphate receptor (IP3R) inhibitor. Xestospongin C acts as an inhibitor of the sarcoplasmic/endoplasmic reticulum Ca2+ ATPase (SERCA) pump of internal stores. Xestospongin C blocks IP3-induced Ca2+ release from cerebellar microsomes with an IC50 of 358 nM. Xestospongin C is a valuable tool for investigating the structure and function of IP3Rs and Ca2+ signaling in neuronal and nonneuronal cells.
Structural Formula
Xestospongin C
Source
a marine sponge, Xestospongia sp.
IC50 & Target
Microbial Metabolite
Shipping
Room temperature in continental US; may vary elsewhere.
SMILES
[H][C@]1([C@](CCCCCC[C@@](CCN2CCC3)([H])O[C@@]2([H])[C@]3([H])CCCCCC4)([H])CCC5)N5CC[C@]4([H])O1
In Vivo
Xestospongin C (3 μM; intracerebroventrical injection by a pump for four weeks) ameliorates the disinhibition-like behavior and long term spatial memory deficits of 8-month-old male APP/PS1 mice of Alzheimer's disease.
In Vitro
Xestospongin C (XeC; 10 μM; 1 h before Aβ) pretreatment before Aβ1-42 (20 μM; 24 hours) application displays a significant decrease in the early apoptotic rate (9.87%) compared to the Aβ alone treated group (18.38%). Xestospongin C (10 μM; 1 h before Aβ) and Aβ1-42 (20 μM; 100 s) has significant main effects on the peak value and average values of Ca2+ changes, as well as a significant interaction in primary cultured hippocampal neurons.
Datasheet 
