Description
Quinine is an alkaloid derived from the bark of the cinchona tree, acts as an anti-malaria agent. Quinine is a potassium channel inhibitor that inhibits WT mouse Slo3 (KCa5.1) channel currents evoked by voltage pulses to +100 mV with an IC50 of 169 μM.
Solubility
DMSO : ≥ 100 mg/mL(308.24 mM ) H2O : 0.1 mg/mL(0.31 mM;Need ultrasonic)
Source
Plants >Rubiaceae > Cinchona succirubraPav. ex Klotzsch
Storage
4℃, protect from light, stored under nitrogen
Shipping
Room temperature in continental US; may vary elsewhere.
SMILES
O[C@H](C1=CC=NC2=C1C=C(OC)C=C2)[C@@]3([H])[N@](C[C@@H]4C=C)CC[C@H]4C3
In Vivo
Quinine (oral gavage, 12 or 15 mg/kg, every week, 16 weeks) has some tumor suppressing effect on skin cancer in Swiss albino mice. Quinine (oral gavage, 10 mg/kg, everyday, 8 weeks) causes a decrease in the antioxidant defense system of rat testicular tissue such as SOD, CAT and GSH enzyme activity in male adult albino rats.Animal Model:Swiss albino mice 7-8-weeks (weighing 24 g)Dosage:12 mg/kg, 15 mg/kgAdministration:Oral gavage; every week; 16 weeksResult:Resulted in a significant reduction in tumor size and weight at 12 mg/kg and little effect at higher dose of 15 mg/kg.
In Vitro
Quinine (37.5-150 μM, 24 hours) significantly reduces viral DENV RNA and protein levels in a dose-dependent manner in human hepatocarcinoma HepG2 cell line.
Datasheet 
