Synonyms
RFS 2000; 9-Nitrocamptothecin
Description
Rubitecan (RFS 2000), a Camptothecin derivative, is an orally active topoisomerase I inhibitor with broad antitumor activity, and induces protein-linked DNA single-strand breaks, thereby blocking DNA and RNA synthesis in dividing cells.
Structural Formula
Rubitecan
Solubility
DMSO : 125 mg/mL(317.78 mM;Need ultrasonic)
Source
Plants >Nyssaceae > Camptotheca acuminataDecne.
Shipping
Room temperature in continental US; may vary elsewhere.
SMILES
O=C1[C@](O)(CC)C2=C(CO1)C(N3CC4=CC5=C([N+]([O-])=O)C=CC=C5N=C4C3=C2)=O
In Vitro
Rubitecan (RFS 2000) inhibits U-CH1, U-CH2, and CCL4 cells with IC50s 0.32, 0.83, and 7.7 µM, respectively.
Datasheet 
