Product Name
Ethoxysanguinarine
Description
Ethoxysanguinarine is a benzophenanthridine alkaloid natural product that is mainly found in Macleaya cordata. Ethoxysanguinarine is an inhibitor of protein phosphatase 2A (CIP2A). Ethoxysanguinarine induces cell apoptosis and inhibits colorectal cancer cells growth.
Structural Formula
Ethoxysanguinarine
Solubility
DMSO : 60 mg/mL(158.99 mM;Need ultrasonic) H2O : (insoluble)
Source
Plants >Papaveraceae > Macleaya cordata(Willd.) R. Br.
Storage
4℃, protect from light
Shipping
Room temperature in continental US; may vary elsewhere.
SMILES
CN1C2=C3C(C=C4OCOC4=C3)=CC=C2C5=C(C6=C(OCO6)C=C5)C1OCC
In Vivo
Ethoxysanguinarine (0.5 mg/kg; s.c.; 5 times per week; 4 weeks) represses colorectal cancer (CRC) xenograft tumors growth in mice.
In Vitro
Ethoxysanguinarine inhibits cells vialibity with IC50 of 9.37 μM (SW480 cells); 7.19 μM (HCT116 cells); 6.55 μM (HT69 cells); 3.57 μM (SW620 cells).Ethoxysanguinarine (3 μM or 5 μM, 24 h) down-regulates phospho-Akt, decreases CIP2A/PP2A/Akt pathway expression in the SW620 and HT29 cells. Ethoxysanguinarine (3 μM or 5 μM, 24 h) increases the PP2A activity and inhibits phosphorylation of CIP2A downstream molecule protein kinase B. Ethoxysanguinarine (1-3 μM or 4.5-5 μM, 24 h) decreases CIP2A transcription (protein level) and induces CIP2A proteolysis in the SW620 and HT29 cells.
Datasheet 
