Product Name
Quinine hemisulfate
Description
Quinine hemisulfate is an orally active alkaloid extracted from cinchona bark and can be used in anti-malarial studies. Quinine hemisulfate is a potassium channel inhibitor that inhibits WT mouse Slo3 (KCa5.1) channel currents evoked by voltage pulses to +100 mV with an IC50 of 169 μM.
Structural Formula
Quinine hemisulfate
Source
Plants >Rubiaceae > Cinchona succirubraPav. ex Klotzsch
Storage
4℃, protect from light, stored under nitrogen
Shipping
Room temperature in continental US; may vary elsewhere.
SMILES
O[C@@H]([C@@]1([H])[N@@](CC2)C[C@H](C=C)[C@@H]2C1)C3=CC=NC4=CC=C(OC)C=C34.O=S(O)(O)=O.[1/2]
In Vivo
Quinine hemisulfate (oral gavage, 12 or 15 mg/kg, every week, 16 weeks) has some tumor suppressing effect on skin cancer in Swiss albino mice.Quinine hemisulfate (oral gavage, 10 mg/kg, everyday, 8 weeks) causes a decrease in the antioxidant defense system of rat testicular tissue such as SOD, CAT and GSH enzyme activity in male adult albino rats.
In Vitro
Quinine hemisulfate (150 μM, 30 min) inhibits the proliferation and cytostatic effects of DENV (Dengue virus) in human hepatocarcinoma HepG2 cell line.Quinine hemisulfate (37.5-150 μM, 24 hours) significantly reduces viral DENV RNA and protein levels in a dose-dependent manner in human hepatocarcinoma HepG2 cell line.
Datasheet 
