Product Name
Berberine chloride
Synonyms
Natural Yellow 18 chloride
Description
Berberine chloride is an alkaloid that acts as an antibiotic. Berberine chloride induces reactive oxygen species (ROS) generation and inhibits DNA topoisomerase. Antineoplastic properties.
Structural Formula
Berberine chloride
Solubility
DMSO : 12.5 mg/mL(33.62 mM;Need ultrasonic) H2O : (insoluble)
Source
Plants >Rutaceae > Phellodendron amurenseRupr.
Storage
4℃, sealed storage, away from moisture
Shipping
Room temperature in continental US; may vary elsewhere.
SMILES
COC1=C(OC)C2=C[N+]3=C(C(C(CC3)=C4)=CC5=C4OCO5)C=C2C=C1.[Cl-]
In Vivo
Berberine (10, 30, or 50 mg/kg/day; gastrointestinal gavage; for 10 consecutive days) inhibits the growth of human colorectal adenocarcinoma in vivo. Berberine at doses of 30 and 50 mg/kg/day taken by gastrointestinal gavage shows inhibitory rates of 33.1% and 45.3% on the human colorectal adenocarcinoma xenograft growth in nude mice.
In Vitro
Berberine (1.25-160 μM; 72 hours) has potential inhibitory effects on the proliferation of four colorectal carcinoma cell lines LoVo, HCT116, SW480, and HT-29.
Datasheet 
