Description
Angoline is a potent and selective IL6/STAT3 signaling pathway inhibitor with an IC50 of 11.56 μM. Angoline inhibits STAT3 phosphorylation and its target gene expression, and inhibits cancer cell proliferation.
Structural Formula
Angoline
Solubility
DMSO : 20.83 mg/mL(54.90 mM;Need ultrasonic)
Source
Plants >Papaveraceae > Macleaya cordata(Willd.) R. Br.
Storage
4℃, protect from light
Shipping
Room temperature in continental US; may vary elsewhere.
SMILES
CN1C2=C3C(C=C4OCOC4=C3)=CC=C2C5=C(C(OC)=C(OC)C=C5)C1OC
In Vitro
Angoline (0-100 μM; 1 h) inhibits STAT3, STAT1 and NF-κB signaling pathways with IC50 values of 11.56, ＞100 and ＞100 μM, respectively.Angoline (0-100 μM; 2 h) affects phosphorylation of STAT3.Angoline (0-100 μM; 72 h) inhibits MDA-MB-231, H4 and HepG2 cells proliferation.
Datasheet 
