Dehydrocorydaline chloride

Name: Dehydrocorydaline chloride
SKU: ALK-0209

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Cat#

ALK-0209

Product Name

Dehydrocorydaline chloride

CAS No.

10605-03-5

Synonyms

13-Methylpalmatine chloride

Description

Dehydrocorydaline chloride (13-Methylpalmatine chloride) is an alkaloid that regulates protein expression of Bax, Bcl-2; activates caspase-7, caspase-8, and inactivates PARP. Dehydrocorydaline chloride elevates p38 MAPK activation. Anti-inflammatory and anti-cancer activities. Dehydrocorydaline chloride shows strong anti-malarial effects (IC50 =38 nM), and low cytotoxicity (cell viability > 90%) using P. falciparum 3D7 strain.

Structural Formula

Dehydrocorydaline chloride

401.88

C22H24ClNO4

Purity

0.9972

Appearance

Solid

Solubility

DMSO : 25 mg/mL(62.21 mM;Need ultrasonic)

Source

Plants >other families

Storage

4℃, sealed storage, away from moisture

Shipping

Room temperature in continental US; may vary elsewhere.

SMILES

CC1=C(C=CC(OC)=C2OC)C2=C[N+]3=C1C4=CC(OC)=C(OC)C=C4CC3.[Cl-]

In Vivo

Dehydrocorydaline (3.6, 6 or 10 mg/kg, i.p.) shows a dose-dependent antinociceptive effect in the acetic acid-induced writhing test and significantly attenuates the formalin-induced pain responses in mice. In the formalin test, dehydrocorydaline decreases the expression of caspase 6 (CASP6), TNF-α, IL-1β and IL-6 proteins in the spinal cord. These findings confirm that Dehydrocorydaline has antinociceptive effects in mice.

In Vitro

Treatment of C2C12 myoblasts with 500 nM Dehydrocorydaline increases the expression levels of muscle-specific proteins, including MyoD, myogenin and myosin heavy chain. Treatment with Dehydrocorydaline elevates p38 MAPK activation and the interaction of MyoD with an E protein. Furthermore, defects in differentiation-induced p38 MAPK activation and myoblast differentiation induced by depletion of the promyogenic receptor protein Cdo in C2C12 myoblasts are restored by Dehydrocorydaline treatment.

Datasheet

For research or industrial raw materials, not for personal medical use!

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