Product Name
Jatrorrhizine hydroxide
Description
Jatrorrhizine hydroxide is an alkaloid isolated from Coptis chinensis with neuroprotective, antimicrobial, antiplasmodial and antioxidant activities. Jatrorrhizine hydroxide is a potent and orally active inhibitor of AChE (IC50=872 nM) over >115-fold selectivity for BuChE. Jatrorrhizine hydroxide reduces uptake of serotonin (5-HT) and norepinephrine (NE) via inhibition of uptake-2 transporters.
Structural Formula
Jatrorrhizine hydroxide
Solubility
H2O : 5 mg/mL(14.07 mM;Need ultrasonic) DMSO : 3.33 mg/mL(9.37 mM;Need ultrasonic)
Source
Plants >Ranunculaceae > Coptis chinensisFranch.
Storage
4℃, protect from light
Shipping
Room temperature in continental US; may vary elsewhere.
SMILES
COC1=C(OC)C2=C[N+]3=C(C4=CC(OC)=C(O)C=C4CC3)C=C2C=C1.[OH-]
In Vivo
Jatrorrhizine (intraperitoneal injection; 5, 10, 20 mg/kg) can significantly reduce the duration of immobility when compared with vehicle control group in tail suspension test (TST).
In Vitro
Jatrorrhizine has antiplasmodial and antiamoebic activity, it against Plasmodium falciparum and E. histolytica with IC50 values of 3.15 and 82.7 µM, respectively.The hOCT2 (organic cation transporter 2), hOCT3, and PMAT (plasma membrane monoamine transporter) are capable of transporting monoamine neurotransmitters in the brain.
Datasheet 
