Synonyms
(+)-Corydaline; Corydalin
Description
Corydaline ((+)-Corydaline), an isoquinoline alkaloid isolated from Corydalis yanhusuo, is an AChE inhibitor with an IC50 of 226 µM. Corydaline is a μ-opioid receptor (Ki of 1.23 µM) agonist and inhibits enterovirus 71 (EV71) replication (IC50 of 25.23 µM). Corydaline has anti-angiogenic, anti-allergic and gastric-emptying and antinociceptive activities.
Solubility
DMSO : 33.33 mg/mL(90.22 mM;Need ultrasonic)
Source
Plants >Papaveraceae > Corydalis yanhusuoW. T. Wang
Shipping
Room temperature in continental US; may vary elsewhere.
SMILES
C[C@@H](C1=CC=C2OC)[C@]3([H])C4=CC(OC)=C(OC)C=C4CCN3CC1=C2OC
In Vivo
Corydaline (10 mg/kg; subcutaneous administration; once) treatment shows antinociceptive effects in mice by significantly inhibiting the writhing behavior.
In Vitro
Corydaline (12.5-50 µM; 24 hours) treatment inhibits EV71 replication by suppressing the COX-2 expression and the phosphorylation of JNK MAPK and P38 MAPK but not ERK MAPK in vitro. Corydaline could inhibit the viral RNA synthesis in a dose dependent manner.
Datasheet 
