Product Name
Norisoboldine
Synonyms
(+)-Laurelliptine
Description
Norisoboldine is an orally active natural aryl hydrocarbon receptor (AhR) agonist. Norisoboldine, as a major isoquinoline alkaloid present in Radix Linderae, can be used for the research of Rheumatoid arthritis and Ulcerative colitis.
Solubility
DMSO : ≥ 62.5 mg/mL(199.46 mM )
Source
Plants >Lauraceae > Lindera aggregata(Sims) Kosterm.
Storage
4℃, protect from light
Shipping
Room temperature in continental US; may vary elsewhere.
SMILES
OC1=C(OC)C=C2CCN[C@@]3([H])CC4=CC(O)=C(OC)C=C4C1=C23
In Vivo
Norisoboldine (10~40 mg/kg; p.o.; 20 days) significantly reduces the severity of joint swelling and erythema during the course of the experiment. Norisoboldine (40 mg/kg; i.g.; 10 days) induces enhancement of CYP1A1 expression and suppresses expressions of Glut1 and HK2 in colons.
In Vitro
Norisoboldine (1~30 μM; 0~24 hours; CD4+T cells) activates AhR under hypoxic microenvironment and significantly downregulates mRNA expression of miR-31.Norisoboldine (30 μM; 0~24 hours; CD4+T cells) inhibits glycolysis in hypoxia.Norisoboldine (1~30 μM; 0~72 hours; Treg cells) promotes Treg differentiation in hypoxia.Norisoboldine (10, 30 μM) facilitates the disassociation of HSP90/AhR complexes, the nuclear translocation of AhR, and the formation of AhR/ARNT complexes. Norisoboldine induces generation of Treg cells in hypoxia is independent of miR-31.
Datasheet 
