Product Name
Laurotetanine
Synonyms
(+)-Laurotetanine
Description
Laurotetanine ((+)-Laurotetanine) is an potent and orally active isoquinoline alkaloid and could be extracted from the roots of Litsea cubeba (Lour.) Pers. Laurotetanine exerts an anti-asthmatic effect by inhibition of IgE, histamine, and inflammatory reactions via down-regulating MUC5AC and NF-κB signaling pathways.
Structural Formula
Laurotetanine
Source
Plants >Lauraceae > Lindera aggregata(Sims) Kosterm.
Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Shipping
Room temperature in continental US; may vary elsewhere.
SMILES
OC1=C(C=C2C3=C4C(CCN[C@]4(CC2=C1)[H])=CC(OC)=C3OC)OC
In Vivo
Laurotetanine ((+)-Laurotetanine; 20-60 mg/kg; p.o.; daily, for 21 d; Sprague Dawley (SD) rats) has anti-asthmatic effect in rats by down-regulating MUC5AC and NF-κB signaling pathways. Animal Model:Sprague Dawley (SD) rats (180-220g) Dosage:20, 40, and 60 mg/kgAdministration:Oral administration; daily, for 21 daysResult:Reduced inflammatory cells, including eosinophils, neutrophils, lymphocytes, and macrophages.Decreased inflammatory cytokines viz IL-4, IL-6, IL-13 and increased IFN-γ.Reduced serum IgE and histamine.Decreased MUC5AC expression and increased NF-κB and IκB expression in lung tissues.
Datasheet 
