Catalog Number: RNPP-74354829
| Size: 200µl 2ml Customization | Inquiry |
|---|
| Gene ID: | PP7435_Chr4-0580 |
| Gene Name: | GET3 |
| Gene Location: | chr4: 980593..981627 |
| DNA Length (bp): | 1035 |
| Protein Length (aa): | 344 |
| Gene Description: |
ATPase GET3 (EC 3.6.-.-) (Arsenical pump-driving ATPase) (Arsenite-stimulated ATPase) (Golgi to ER traffic protein 3) (Guided entry of tail-anchored proteins 3) ATPase required for the post-translational delivery of tail-anchored (TA) proteins to the endoplasmic reticulum Recognizes and selectively binds the transmembrane domain of TA proteins in the cytosol This complex then targets to the endoplasmic reticulum by membrane-bound receptors GET1 and GET2, where the tail-anchored protein is released for insertion This process is regulated by ATP binding and hydrolysis ATP binding drives the homodimer towards the closed dimer state, facilitating recognition of newly synthesized TA membrane proteins ATP hydrolysis is required for insertion Subsequently, the homodimer reverts towards the open dimer state, lowering its affinity for the GET1-GET2 receptor, and returning it to the cytosol to initiate a new round of targeting Cooperates with the HDEL receptor ERD2 to mediate the ATP-dependent retrieval of resident ER proteins that contain a C-terminal H-D-E-L retention signal from the Golgi to the ER Involved in low-level resistance to the oxyanions arsenite and arsenate, and in heat tolerance |
| Medium: |
YPD + 1M Sorbitol broth 30% glycerol |
| Shipping condition: | Frozen Gel Packs |
| Storage condition/Stability: |
-80℃/At least 12 months 4°C/Up to 1 week |
| Hazardous: | No |
Disclaimer
This product is classified under IATA regulations as a GMMO (genetically modified micro-organism) and will ship as UN3245. If applicable, ensure facility meets all requirements per local and country regulations.
