Catalog Number: RNPP-74352342
| Size: 200µl 2ml Customization | Inquiry |
|---|
| Gene ID: | PP7435_Chr2-0750 |
| Gene Name: | PAN3 |
| Gene Location: | chr2: 1386884..1386914 |
| DNA Length (bp): | 31 |
| Protein Length (aa): | 9 |
| Gene Description: |
PAN2-PAN3 deadenylation complex subunit PAN3 (PAB1P-dependent poly(A)-specific ribonuclease) (Poly(A)-nuclease deadenylation complex subunit 3) (PAN deadenylation complex subunit 3) Regulatory subunit of the poly(A)-nuclease (PAN) deadenylation complex, one of two cytoplasmic mRNA deadenylases involved in mRNA turnover PAN specifically shortens poly(A) tails of RNA and the activity is stimulated by poly(A)-binding protein PAB1 PAN deadenylation is followed by rapid degradation of the shortened mRNA tails by the CCR4-NOT complex Deadenylated mRNAs are then degraded by two alternative mechanisms, namely exosome-mediated 3'-5' exonucleolytic degradation, or deadenlyation-dependent mRNA decaping and subsequent 5'-3' exonucleolytic degradation by XRN1 May also be involved in post-transcriptional maturation of mRNA poly(A) tails PAN3 acts as a positive regulator for PAN activity, recruiting the catalytic subunit PAN2 to mRNA via its interaction with RNA and with PAB1 |
| Medium: |
YPD + 1M Sorbitol broth 30% glycerol |
| Shipping condition: | Frozen Gel Packs |
| Storage condition/Stability: |
-80℃/At least 12 months 4°C/Up to 1 week |
| Hazardous: | No |
Disclaimer
This product is classified under IATA regulations as a GMMO (genetically modified micro-organism) and will ship as UN3245. If applicable, ensure facility meets all requirements per local and country regulations.
