Endoplasmic reticulum (ER) is an important site for synthesizing new peptide chains by a membrane and secreted proteins, and also contains the initial folding modification of new peptide chains. But folding and modification process is complex and error-prone; misfolded proteins in the endoplasmic reticulum quality control (ERQC) system to identify and trap within the endoplasmic reticulum. Once the accumulation of erroneous proteins exceeds the capacity of ER, a series of cellular responses will be triggered to achieve a new ER homeostasis, which is called ER stress response.
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Fig.1 Endoplasmic reticulum quality control system in plants.
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