Comparative and Functional Microalgae Genomics

Introduction

Microalgae have been considered promising hosts for the production of various valuable compounds. With the increased importance of microalgae in biotechnology, environment, and nutritional health, whole genome sequences of different microalgal species have been published. The phenotypic and ecological diversity among microalgae also hints at the range of functional capabilities encoded by microalgal genomes. Genome sequences provide a window into the functional potential of individual algae. In contrast, phylogenomics and functional genomics serve as tools for contextualizing and transferring knowledge of reference organisms to less characterized systems. Comparative genomic analyses can provide additional inferences for protein function prediction and for building confidence in the automated functional annotation. Functional genomics datasets, such as transcriptomics, proteomics, and genome-wide mutation screens, can provide additional layers of gene-specific functional data. These approaches are essential support for studying the evolutionary process in microalgae.

Fig 1. Genome analysis and genetic transformation of a water surface-floating microalga Chlorococcum sp. FFG039. (Maeda Y, et al., 2019)

Customized Solutions

To explore microalgae's biodiversity and fully exploit their commercial potential, our skilled scientists try to understand their evolution, structure, function, and development at the genomic level. Lifeasible provides customers with specialized comparative and functional microalgae genomics services to support your research in the evolutionary process of microalgae and to create microalgae-based products. Our solutions include:

Structural Annotation of Microalgal Genomes

• Raw genome sequences are difficult to understand the biological functions of microalgae. We provide complete and accurate structural annotation of microalgal genomes to analyze the position of genomic features in the assembly, such as genes, coding sequences, transcription start and stop sites, and optional splice sites.

Functional Annotation of Microalgal Genomes

• Our scientists integrate and utilize available genomic and post-genomic data to decode the functional significance of specific gene sequences in microalgae in a biological context.
• We use comparative genomic analysis to identify protein families from various microalgae containing fusion proteins.
• We use functional genomic analysis to determine specific conditions for protein expression, protein localization, protein function prediction, etc.

Advantages of Our Solutions

• High-quality genome sequences and high-quality structural annotation of microalgal genes.
• Reliable microalgal protein function prediction.
• Proven automated functional annotation platform for microalgal genomes.
• Access to rich and comprehensive microalgal comparative genomic and functional genomics datasets.
• Essential support for studying the evolutionary process of microalgae.
• Advanced CRISPR-Cas system and other genome engineering technologies.

The microalgal genome encodes a large number of proteins of unknown function. We provide comprehensive comparative genomic and analytical, functional genomic data to help you develop new microalgal proteins and predict protein function. If you are interested in our solutions, please contact us directly.